MOLECULAR GENETICS OF THE HLA-D REGION COMPONENT OF INHERITED SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS
نویسندگان
چکیده
منابع مشابه
HLA class III region and susceptibility to rheumatoid arthritis.
OBJECTIVE We examined the contribution of the HLA class III region in susceptibility to rheumatoid arthritis (RA). METHODS Patients with RA, healthy subjects and homozygous typing cell (HTC) lines were typed for HLA class I (A, B, C), class II (DR, DQ) and class III (D6S273, Bat 2, and TNFa microsatellites, and HSP70 promoter region) alleles by molecular techniques. RESULTS Based on the dis...
متن کاملLack of influence of non - inherited maternal HLA - DR alleles on susceptibility to rheumatoid arthritis Alan
Objective-To reproduce findings from previous reports that non-inherited maternal HLA class II antigens might contribute to rheumatoid arthritis (RA) susceptibility in the offspring. Methods-Families were recruited from the Arthritis and Rheumatism Council's National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA typi...
متن کاملLack of influence of non-inherited maternal HLA-DR alleles on susceptibility to rheumatoid arthritis.
OBJECTIVE To reproduce findings from previous reports that non-inherited maternal HLA class II antigens might contribute to rheumatoid arthritis (RA) susceptibility in the offspring. METHODS Families were recruited from the Arthritis and Rheumatism Council's National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA ty...
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In the present paper, we used the North American Rheumatoid Arthritis Consortium data provided for Genetic Analysis Workshop 15 Problem 2 to: 1) estimate the penetrances of PTPN22 and HLA-DRB1 and, 2) test the selected model of PTPN22 conditional on the rheumatoid factor status. To achieve these aims, we used the marker association segregation chi-square method, fitting simultaneously both geno...
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background: rheumatoid arthritis (ra) is the most common chronic inflammatory erosive joint disease with the worldwide distribution of approximately 0.5-1%. molecular methods can be very sensitive in the early stage diagnosis of the disease and therefore prevention the late complications and disabilities. etiology of ra, an autoimmune disease, is not exactly known but immunologic and genetic fa...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 1988
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/27.3.171